Optimization of Product Quality for an API Manufacturing Plant
Context
An Active Pharmaceutical Ingredient (API) manufacturing plant was not able to identify issues with its separation process including a crystallizer and associated ancillary equipment, which resulted in increasing off-spec product quality.
Solution
The plant used Aleph AI Co-Pilot platform to predict batch output quality and alert the users on potential deviations, including the diagnosis of the potential causes. The plant has also been relying on Aleph AI’s recommendation to ensure swift response against quality deviations.
Outcome
Aleph AI identified the initial causes as suboptimal operating conditions on impeller speeds of compactors and feed flow rates. Aleph AI Co-Pilot has since been generating recommendations to prevent quality deviation for the plant, enabling a 21% improvement on output quality.